HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2197663Generated: October 27, 2026
methyl-(R)-4-(1-carbamoylpropylamino)butyrate → Etiracetam, (R)-
https://huagongshe.com/reaction/2197663
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | methyl-(R)-4-(1-carbamoylpropylamino)butyrate | HCID 59650081 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Etiracetam, (R)- | HCID 441341 | 30% |
Reaction Steps
To the crude methyl-(R)-4-(1-carbamoylpropylamino)butyrate (VIf) in toluene (20 ml) is added 2-hydroxypyrridine (50 mg, 10 mol %). The mixture is heated to 80° C. until complete conversion. After 16 hours (GC: 100% conversion) the mixture is concentrated to dryness to yield (R)-2-(2-oxopyrrolidin-1-yl)butyramide (0.28 g, 1.6 mmol, 30%, yield determination by GC assay from pure standard).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08338621B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-4366f7dfe47c471d9ff801267fc62ee2 |
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| Source note | uspto-grants-2012_12 |
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