HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2197690Generated: October 25, 2026
Diphenyl Ether → Ethyl 7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate
https://huagongshe.com/reaction/2197690
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diphenyl Ether | HCID 7583 | — |
| Reactant | Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate | HCID 83264 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | Ethyl 7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate | HCID 5373687 | 71% |
Reaction Steps
A solution of diphenyl ether was heated to 250° C. and the product of Example 1a (2.50 g, 9.0 mmol) was added in several small portions over a period of about 5 min then heated at 250° C. for 30 min. After cooling to room temperature diluted with hexane. The resulting solid was filtered and was dried under vacuum giving the title compound as a tan solid (1.47 g, 71%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08338605B2 |
|---|
| Source dataset | uspto-grants-2012_12 |
|---|
| ORD ID | ord-a1d2c090bb7344c68a13d0d54f93a80e |
|---|
| Source note | uspto-grants-2012_12 |
|---|
