HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-methyl-8H-1,8-naphthyridin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate | HCID 5373687 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-methyl-8H-1,8-naphthyridin-4-one | HCID 178422956 | 83% |
Reaction Steps
A solution of the product from Example 1b (1.30 g, 5.59 mmol) and NaOH (233 mg, 5.82 mmol) in 20 mL of water was heated in a sealed metal reactor at 180° C. for 16 h. Cooled to room temperature and adjusted to pH 6 with 1N HCl. The resulting precipitates was filtered and dried under vacuum giving the title compound as a black solid (743 mg, 82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338605B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-36e719fb78174f389e3818955048c612 |
| Source note | uspto-grants-2012_12 |