HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl (ethoxymethylene)malonate → Diethyl 2-((6-propylpyridin-2-ylamino)methylene)malonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 6-Propylpyridin-2-amine | HCID 3016309 | — |
| Product | Diethyl 2-((6-propylpyridin-2-ylamino)methylene)malonate | HCID 68461848 | — |
Reaction Steps
The product from Example 2c (223 mg, 1.52 mmol) was reacted with 2-ethoxymethylene-malonic acid diethyl ester 0.350 mL, 1.75 mmol) following the procedure in Example 1a to give the title compound after silica gel column chromatography eluting with EtOAc/hexane (386 mg, 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338605B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-f61e9a5fd4c947de8bd7237bd44ad55d |
| Source note | uspto-grants-2012_12 |