HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → Ethyl 4-chloro-7-methyl-1,8-naphthyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Ethyl 7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate | HCID 5373687 | — |
| Product | Ethyl 4-chloro-7-methyl-1,8-naphthyridine-3-carboxylate | HCID 10562672 | 57% |
Reaction Steps
The product from Example 1b (1.0 g, 4.30 mmol) was reacted with 12 mL of POCl3 for 4 h following the procedure from Example 1d giving the title compound as a brownish-pink solid (619 mg, 57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338605B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-fda1afc50c544ff884797515c4a84653 |
| Source note | uspto-grants-2012_12 |