2,5-Dichloro-1,8-naphthyridine → N-{4-[2-(7-Chloro-[1,8]naphthyridin-4-ylamino)-4-methyl-phenylsulfanyl]-phenyl}-acetamide

HRID 2197735Notes

Reaction equation

HRID 2197735 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[N:5][CH:6]=[CH:7][C:8]=2Cl)[N:3]=1.[NH2:13][C:14]1[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:15]=1[S:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29](=[O:31])[CH3:30])=[CH:24][CH:23]=1>>[Cl:1][C:2]1[N:3]=[C:4]2[C:9]([C:8]([NH:13][C:14]3[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:15]=3[S:21][C:22]3[CH:27]=[CH:26][C:25]([NH:28][C:29](=[O:31])[CH3:30])=[CH:24][CH:23]=3)=[CH:7][CH:6]=[N:5]2)=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 155883162,5-Dichloro-1,8-naphthyridineHCID 43168935N-[4-(2-Amino-4-methyl-phenylsulfanyl)-phenyl]-acetamide

Product 1

HCID 86615485N-{4-[2-(7-Chloro-[1,8]naphthyridin-4-ylamino)-4-methyl-phenylsulfanyl]-phenyl}-acetamideYield 48%

Procedure

The product from Example 13d (200 mg, 1.0 mmol) and the product from Example 18b (215 mg, 1.0 mmol) were reacted following the procedure from Example 1g giving a crude solid that was purified by HPLC with TFA to give the title compound 200 mg, 48%).

Workup

  1. customgiving a crude solid
  2. customthat was purified by HPLC with TFA

Sources & evidence

ORD record
ord-f5102167b87545fe8e80c37fd65a0bda
Source dataset
uspto-grants-2012_12
Patent number
US08338605B2

Reaction notes

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