3-Thiocresol → HCID 68459002, compound

HRID 2197764Notes

Reaction equation

HRID 2197764 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5](OS(C(F)(F)F)(=O)=O)=[C:4]([N+:16]([O-:18])=[O:17])[CH:3]=1.[CH3:19][C:20]1[CH:21]=[C:22]([SH:26])[CH:23]=[CH:24][CH:25]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:26][C:22]2[CH:21]=[C:20]([CH3:19])[CH:25]=[CH:24][CH:23]=2)=[C:4]([N+:16]([O-:18])=[O:17])[CH:3]=1

Participants

3

Reactant 2

HCID 79303-ThiocresolHCID 713468894-Methyl-2-nitrophenyl trifluoromethanesulfonate

Product 1

HCID 68459002HCID 68459002, compound

Procedure

The product from Example 4a (9.46 g, 33.17 mmol) was reacted with 3-methylthiophenol (4.12 g, 33.17 mmol) in place of thiophenol following the procedure from Example 1e for 18 h giving the crude title compound which was purified by silica gel column chromatography eluting with 5% EtOAc hexane providing a solid (7.50 g, 87%).

Sources & evidence

ORD record
ord-570930c799714a02b834b559e7cb3dc5
Source dataset
uspto-grants-2012_12
Patent number
US08338605B2

Reaction notes

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