HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorothiophenol → 1-(4-Fluoro-phenylsulfanyl)-4-methyl-2-nitro-benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorothiophenol | HCID 67789 | — |
| Reactant | 4-Methyl-2-nitrophenyl trifluoromethanesulfonate | HCID 71346889 | — |
| Product | 1-(4-Fluoro-phenylsulfanyl)-4-methyl-2-nitro-benzene | HCID 60204794 | — |
Reaction Steps
The product from Example 4a (5.00 g, 17.53 mmol) was reacted with 4-fluorothiophenol (2.24 g, 17.53 mmol) in place of thiophenol following the procedure from Example 1e for 18 h giving the crude title compound which was purified by silica gel column chromatography eluting with 5% EtOAc hexane providing a solid (3.39 g, 74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338605B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-8378cd7c8f14469db337a309393957b3 |
| Source note | uspto-grants-2012_12 |