Stannous Chloride → 2-(4-Fluoro-phenylsulfanyl)-5-methyl-phenylamine

HRID 2197768Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:10]=2[N+:16]([O-])=O)=[CH:4][CH:3]=1.Cl[Sn]Cl>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:10]=2[NH2:16])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 24479Stannous Chloride

HCID 602047941-(4-Fluoro-phenylsulfanyl)-4-methyl-2-nitro-benzene

Product 1

HCID 431689322-(4-Fluoro-phenylsulfanyl)-5-methyl-phenylamine

Procedure

The product from Example 49a was reduced with SnCl2 following the procedure from Example 1f giving the title compound.

Sources & evidence

ORD record: ord-6ba279b422294a43b1be4030147e30ca
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08338605B2

Reaction notes

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