HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-3-thiopheneboronic acid → Methyl 3-methoxy-4-(4-methyl-3-thienyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-3-thiopheneboronic acid | HCID 5083931 | — |
| Reactant | Methyl 4-bromo-3-methoxybenzoate | HCID 14570117 | — |
| Reactant | 3-Methyl-4-[2-(trifluoromethyl)phenyl]benzoic acid | HCID 21947812 | — |
| Product | Methyl 3-methoxy-4-(4-methyl-3-thienyl)benzoate | HCID 67400074 | — |
Reaction Steps
The title compound was prepared following procedure described for Intermediate 5, step 1, but starting from methyl 4-bromo-3-methoxybenzoate (Combi-Blocks, 2.50 g; 10.20 mmol; 1 eq.) and 4-methyl-3-thiopheneboronic acid (1.59 g; 11.22 mmol; 1.10 eq.), and was isolated as a brown oil. It was used in the next step without further purification. LC/MS (Method A): 262.8 (M+H)+. HPLC (Method A) Rt 4.79 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202865B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-7d8965b4a54c45388d0ca83d52c83b3c |
| Source note | uspto-grants-2012_06 |