Diisopropylethylamine → HCID 86615491, compound

Participants

Reaction Steps

The product from Example 6 (120 mg, 0.274 mmol) was reacted with isopropyl sulfonyl chloride (43 mg, 0.30 mmol), N,N-diisopropylethylamine (43 mg, 0.33 mmol), and catalytic DMAP in CH2Cl2 for 18 h giving the crude title compound which was purified by HPLC with TFA providing the product as the trifluoroacetic acid (40 mg, 23%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 8.75 (d, J=8.54 Hz, 1H) 8.20 (d, J=6.71 Hz, 1H) 7.58 (d, J=8.54 Hz, 1H) 7.26 (d, J=7.93 Hz, 1H) 7.17-7.21 (m, 2H) 7.08 (d, J=9.16 Hz, 2H) 6.95 (d, J=8.54 Hz, 2H) 6.15 (d, J=6.71 Hz, 1H) 3.43-3.51 (m, J=13.43, 1H) 2.79 (t, J=7.63, 7.63 Hz, 2H) 2.20 (s, 3H) 1.61-1.67 (m, 2H) 1.21 (d, J=6.71 Hz, 6H) 0.78 (t, J=7.32 Hz, 3H); MS (ESI+) m/z 508 (M+H)+.

Provenance & Evidence