Ethanesulfonyl chloride → HCID 86615493, compound

Participants

Reaction Steps

The product from Example 6 (100 mg, 0.228 mmol) was reacted with ethane sulfonyl chloride (28 mg, 0.228 mmol), N,N-diisopropylethylamine (88.5 mg, 0.685 mmol), and catalytic DMAP in dichloroethane for 18 h giving the crude title compound which was purified by HPLC with TFA providing the product as the trifluoroacetic acid (30 mg, 22%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 0.97 (t, J=7.35 Hz, 3H) 1.34 (t, J=7.17 Hz, 3H) 1.79-1.87 (m, 2H) 2.40 (s, 3H) 2.98 (t, J=7.54 Hz, 2H) 3.47 (q, J=7.35 Hz, 2H) 6.34 (d, J=7.35 Hz, 1H) 7.14-7.19 (m, 2H) 7.27 (d, 2H) 7.39 (s, 2H) 7.46 (d, 1H) 7.78 (d, J=8.46 Hz, 1H) 8.39 (d, J=6.99 Hz, 1H) 8.92 (d, J=8.82 Hz, 1H); MS (ESI+) m/z 494 (M+H)+.

Provenance & Evidence