5-Chloro-2-methyl-1,8-naphthyridine → HCID 68461520, compound

Participants

Reaction Steps

The product from Example 1d (106 mg, 0.59 mmol) was reacted in ethanol (2 mL) with the product from Example 106b (200 mg, 0.59 mmol) for 18 h following the procedure from Example 1g giving the crude title compound which was purified by HPLC with TFA providing the product as a trifluoroacetic acid salt (53 mg, 19%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 2.05 (s, 3H) 2.77 (s, 3H), 6.41 (d, J=6.99 Hz, 1H), 7.02 (d, J=8.82 Hz, 1H), 7.33 (d, J=8.46 Hz, 2H), 7.58 (d, J=8.82 Hz, 2H), 7.65 (dd, J=8.46, 2.21 Hz, 1H) 7.77 (d, J=2.21 Hz, 1H), 7.81 (d, J=8.82 Hz, 1H), 8.48 (d, J=6.99 Hz, 1H), 8.96 (d, J=8.82 Hz, 1H), 10.11 (s, 1H), 11.06 (s, 1H), 14.53 (s, 1H); MS (DCI/NH3) m/z 479 (M+H)+.

Provenance & Evidence