HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-(4-Chloro-2-nitrophenoxy)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-(4-Chloro-2-nitrophenoxy)benzoic acid | HCID 2442252 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(4-Chloro-2-nitrophenoxy)benzoyl chloride | HCID 86615494 | 100% |
Reaction Steps
The product from Example 126b (4.0 g, 13.6 mmol) in 40 mL of CH2Cl2 was treated with oxalyl chloride (3.5 g, 27.2 mmol) and DMF (catalytic amount). Mixture was stirred for 12 hours. Mixture was concentrated under vacuum giving the title compound as a yellow oil (4.2 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338605B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-d55f472e4277449bbe57b36f047272f7 |
| Source note | uspto-grants-2012_12 |