HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylethylamine → 4-(4-chloro-2-nitrophenoxy)-N-ethyl-N-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylethylamine | HCID 12219 | — |
| Reactant | 4-(4-Chloro-2-nitrophenoxy)benzoyl chloride | HCID 86615494 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(4-chloro-2-nitrophenoxy)-N-ethyl-N-methylbenzamide | HCID 68459712 | — |
Reaction Steps
The compound from Example 126c (1.0 g, 3.2 mmol) in CH2Cl2 was added to a mixture of N-methylethanamine (379 mg, 6.41 mmol) in CH2Cl2. Mixture was stirred for 12 hours. Mixture was concentrated under vacuum giving the title compound, which was purified by silica gel column chromatography eluting with 50% EtOAc/hexane giving a yellow oil (1.03 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338605B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-e9fd660c7e894369a30b2a831f8a6184 |
| Source note | uspto-grants-2012_12 |