5-Chloro-2-methyl-1,8-naphthyridine → HCID 68461218, compound

Participants

Reaction Steps

The product from Example 1d (53 mg, 0.30 mmol) was reacted with 4-[2-amino-4-(3-fluoro-benzyloxy)-phenylsulfanyl]-phenol (102 mg, 0.30 mmol) for 20 h following the procedure from Example 1g giving the crude title compound which was purified by HPLC with TFA providing the product as a trifluoroacetic acid (60 mg, 33%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 2.76 (s, 3H) 5.16 (s, 2H) 6.27 (d, J=6.99 Hz, 1H) 6.64 (d, J=8.46 Hz, 2H) 7.03-7.36 (m, 7H) 7.45 (m, J=6.26 Hz, 1H) 7.80 (d, J=8.82 Hz, 1H) 8.39 (d, J=6.98 Hz, 1H) 8.99 (d, J=8.82 Hz, 1H) 9.78 (s, 1H) 11.02 (br s, 1H) 14.39 (br s, 1H); MS (ESI+) m/z, 484 (M+H−TFA)+; (ESI−) m/z, 482 (M−H−TFA)−.

Provenance & Evidence