反应详情

The product from Example 1d (53 mg, 0.30 mmol) was reacted with 4-[2-amino-4-(4-fluoro-benzyloxy)-phenylsulfanyl]-phenol (102 mg, 0.30 mmol) for 18 h following the procedure from Example 1g giving the crude title compound which was purified by HPLC with TFA providing the product as a trifluoroacetic acid (115 mg, 64%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 2.76 (s, 3H) 5.11 (s, 2H) 6.26 (d, J=6.99 Hz, 1H) 6.65 (d, J=8.46 Hz, 2H) 7.10 (d, J=8.82 Hz, 2H) 7.15-7.27 (m, 4H) 7.49 (m, J=5.88 Hz, 2H) 7.81 (d, J=8.46 Hz, 1H) 8.40 (d, J=6.98 Hz, 1H) 8.98 (d, J=8.46 Hz, 1H) 9.78 (s, 1H) 11.03 (br s, 1H) 14.36 (br s, 1H); MS (ESI+) m/z, 484 (M+H−TFA)+; (ESI−) m/z, 482 (M−H−TFA)−.