5-Chloro-2-propyl-[1,8]naphthyridine → HCID 68461348, compound

Participants

Reaction Steps

The product from Example 2g (85 mg, 0.41 mmol) was reacted with 4-[2-amino-4-(3-fluoro-benzyloxy)-phenylsulfanyl]-phenol (141 mg, 0.41 mmol) for 24 h following the procedure from Example 1g giving the crude title compound which was purified by HPLC with TFA providing the product as a trifluoroacetic acid (95 mg, 37%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 0.98 (t, J=7.36 Hz, 3H) 1.85 (sext, J=7.72 Hz, 2H) 3.00 (dd, J=7.36 Hz, 2H) 5.16 (s, 2H) 6.27 (d, J=7.35 Hz, 1H) 6.66 (d, J=8.83 Hz, 2H) 7.09-7.34 (m, 7H) 7.43 (m, J=6.25 Hz, 1H) 7.83 (d, J=8.83 Hz, 1H) 8.40 (d, J=6.99 Hz, 1H) 9.03 (d, J=8.83 Hz, 1H) 9.80 (s, 1H) 11.04 (br s, 1H) 14.45 (br s, 1H); MS (ESI+) m/z, 512 (M+H−TFA)+; (ESI−) m/z, 510 (M−H−TFA)−.

Provenance & Evidence