反应详情

The product from Example 16c (100 mg, 0.559 mmol) was reacted with 4-(2-amino-4-benzyloxy-phenylsulfanyl)-phenol (224 mg, 0.559 mmol) for 18 h following the procedure from Example 1g giving the crude title compound which was purified by HPLC with TFA providing the product as a trifluoroacetic acid (mg, %). 1H NMR (300 MHz, DMSO-d6) δ ppm: 5.14 (s, 2H), 6.31 (d, J=6.99 Hz, 1H), 6.61-6.69 (m, 2H), 7.08-7.23 (m, 5H), 7.32-7.46 (m, 5H), 7.92 (dd, J=8.46, 4.41 Hz, 1H), 8.47 (d, J=6.99 Hz, 1H), 9.10-9.21 (m, 2H), 9.77 (s, 1H), 11.14 (s, 1H); MS (ESI+) m/z 452 (M+H−TFA)+; (ESI−) m/z 450 (M−H−TFA)−.