Stannous Chloride → 3-(2-Amino-4-chloro-phenoxy)-benzoic acid ethyl ester

HRID 2197910Notes

Reaction equation

HRID 2197910 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=2[N+:19]([O-])=O)[CH:6]=1)[CH3:2].Cl[Sn]Cl>>[CH2:1]([O:3][C:4](=[O:22])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=2[NH2:19])[CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 24479Stannous ChlorideHCID 68461364HCID 68461364, compound

Product 1

HCID 684582963-(2-Amino-4-chloro-phenoxy)-benzoic acid ethyl esterYield 73%

Procedure

The product from Example 169a (1.5 g, 4.7 mmol) was reacted with SnCl2 as described in Example 1f to give the title compound (1.0 g, 73%).

Sources & evidence

ORD record
ord-2e0c6167fac14050ba505c88d07c8d97
Source dataset
uspto-grants-2012_12
Patent number
US08338605B2

Reaction notes

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