Stannous Chloride → [3-(2-Amino-4-chloro-phenoxy)-phenyl]-methanol

HRID 2197923Notes

Reaction equation

HRID 2197923 reaction equation
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][C:7]2[CH:8]=[C:9]([CH2:13][OH:14])[CH:10]=[CH:11][CH:12]=2)=[C:4]([N+:17]([O-])=O)[CH:3]=1.Cl[Sn]Cl>>[NH2:17][C:4]1[CH:3]=[C:2]([Cl:1])[CH:16]=[CH:15][C:5]=1[O:6][C:7]1[CH:8]=[C:9]([CH2:13][OH:14])[CH:10]=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 24479Stannous ChlorideHCID 68456706[3-(4-Chloro-2-nitro-phenoxy)-phenyl]-methanol

Product 1

HCID 61679632[3-(2-Amino-4-chloro-phenoxy)-phenyl]-methanolYield 83%

Procedure

The product from Example 176b (1.9 g, 6.8 mmol) was reacted with SnCl2 as described in Example 1f to give the title compound (1.4 g, 83%).

Sources & evidence

ORD record
ord-8fb83020ef8e4d8e985153df3c56851e
Source dataset
uspto-grants-2012_12
Patent number
US08338605B2

Reaction notes

Loading…