HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2197968Generated: November 1, 2026
Sulfuric Acid → Methyl 4-bromo-3-nitrobenzoate
https://huagongshe.com/reaction/2197968
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 4-Bromo-3-nitrobenzoic acid | HCID 232986 | — |
| Reactant | Water ethylacetate | HCID 22728543 | — |
| Catalyst | Sulfuric Acid | HCID 1118 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4-bromo-3-nitrobenzoate | HCID 2736829 | — |
Reaction Steps
Commercially available 4-bromo-3-nitro-benzoic acid (1.17 g, 4.76 mmol) was dissolved in methanol (5 mL) containing five drops of concentrated sulfuric acid. The mixture was heated in air at 90° C. for six hours and more MeOH (7 mL) followed by concentrated sulfuric acid (0.6 mL) was added. Heating was continued another 24 hours. Extractive work up (ethyl acetate-water) followed by drying over MgSO4, filtered and concentrated under vacuum giving the title compound in quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08338605B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-99bbbe5f8eb44a329162cd8f5efe9ee8 |
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| Source note | uspto-grants-2012_12 |
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