5-Chloro-2-methyl-1,8-naphthyridine → HCID 68459000, compound

Participants

Reaction Steps

The product from Example 1d (0.088 g, 0.49 mmol) was reacted with the product from Example 214b (107 mg, 0.49 mmol) for 65 h following the procedure from Example 1g giving the crude title compound which was purified by HPLC with TFA providing the product as a trifluoroacetic acid salt (0.106 g, 45%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 2.41 (s, 3H) 2.72 (s, 3H) 3.66 (s, 3H) 6.29 (d, J=6.99 Hz, 1H) 6.84 (d, J=8.82 Hz, 2H) 7.27-7.53 (m, 5H) 7.75 (d, J=8.46 Hz, 1H) 8.32 (d, J=6.99 Hz, 1H) 8.90 (d, J=8.46 Hz, 1H) 10.88-11.05 (m, 1H); MS (ESI+) m/z 356.0 (M+H)+; (ESI−) m/z 354.1 (M−H)−.

Provenance & Evidence