5-Chloro-2-methyl-1,8-naphthyridine → HCID 68459604, compound

Participants

Reaction Steps

The product from Example 1d (0.041 g, 0.23 mmol) was reacted with the product from Example 215b (0.062 g, 0.23 mmol) for 46 h at 100° C. following the procedure from Example 1g giving the crude title compound which was purified by HPLC with TFA providing the product as a trifluoroacetic acid salt (0.073 g, 60%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 1.98 (s, 3H) 2.42 (s, 3H) 2.72 (s, 3H) 6.28 (d, J=6.99 Hz, 1H) 7.27-7.56 (m, 7H) 7.74 (d, J=8.46 Hz, 1H) 8.33 (d, J=7.35 Hz, 1H) 8.94 (d, J=8.82 Hz, 1H) 9.95 (s, 1H) 11.06 (s, 1H); MS (ESI+) m/z 383.1 (M+H)+, (ESI−) m/z 381.1 (M−H)−.

Provenance & Evidence