HuagongsheHuagongshe Chemistry Print Report · For research reference only
Undecane → 2-Nitro-4-trifluoromethyl-biphenyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Undecane | HCID 14257 | — |
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | 4-Bromo-3-nitrobenzotrifluoride | HCID 520706 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Catalyst | Dichlorobis(triphenylphosphine)palladium | HCID 6102075 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Nitro-4-trifluoromethyl-biphenyl | HCID 11300119 | — |
Reaction Steps
Commercially available 1-bromo-2-nitro-4-trifluoromethyl-benzene (0.130 g, 0.48 mmol) was reacted with phenylboronic acid (0.072 g, 0.59 mmol) as described in Example 213a substituting dioxane for toluene, bis(triphenylphosphine)-palladium (II) chloride for palladium acetate and omitting the 2,8,9-triisobutyl-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3.]undecane. The reaction was complete after three hours and the title biphenyl recovered in quantitative yield, sufficiently pure for use as isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338605B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-ee885539577b40889c953c456059a234 |
| Source note | uspto-grants-2012_12 |