HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N-{4-[2-Amino-4-(2-methyl-allyloxy)-phenylsulfanyl]-phenyl}-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Bromo-2-methyl-1-propene | HCID 357785 | — |
| Reactant | N-[4-(2-Amino-4-hydroxy-phenylsulfanyl)-phenyl]-acetamide | HCID 67250701 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-{4-[2-Amino-4-(2-methyl-allyloxy)-phenylsulfanyl]-phenyl}-acetamide | HCID 68460644 | 100% |
Reaction Steps
A mixture of the product from Example 232b (56 mg, 0.17 mmol), 2-methyl-3-bromo propene (20 mg, 0.17 mmol) and potassium carbonate (26 mg, 0.19 mmol) in DMF (1 mL) was stirred at room temperature 15 hr. The next day, the reaction mixture was poured onto ice and the solid collected by filtration providing the title compound (55 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338605B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-7ef14b1995fb4f789b39f0ad6a777c83 |
| Source note | uspto-grants-2012_12 |