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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2198021Generated: October 26, 2026

4-Hydroxypyrrolidine → 1-[3-Fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-ol

https://huagongshe.com/reaction/2198021

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-HydroxypyrrolidineHCID 98210—
Reactant2-Bromo-6-fluorobenzotrifluorideHCID 2773345—
Product1-[3-Fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-olHCID 6702226224%

Reaction Steps

The title compound (6.2 g, yield 24%) was obtained from 1-bromo-3-fluoro-2-(trifluoromethyl)benzene and 3-hydroxypyrrolidine by a method similar to that in Reference Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08338622B2
Source datasetuspto-grants-2012_12
ORD IDord-b57590e32b9e42eaad5d61f2b2c47f96
Source noteuspto-grants-2012_12