4-Hydroxypyrrolidine → HCID 86658335, compound

HRID 2198022Notes

Reaction equation

HRID 2198022 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[C:12]([F:15])([F:14])[F:13].[OH:16][CH:17]1[CH2:21][CH2:20][NH:19][CH2:18]1>>[F:13][C:12]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([C:8]([F:11])([F:10])[F:9])[CH:6]=[CH:7][C:2]=1[N:19]1[CH2:20][CH2:21][CH:17]([OH:16])[CH2:18]1

Participants

3

Reactant 2

HCID 982104-HydroxypyrrolidineHCID 1361642,4-Bis(trifluoromethyl)bromobenzene

Product 1

HCID 86658335HCID 86658335, compoundYield 45%

Procedure

The title compound (6.84 g, yield 45%) was obtained from 1-bromo-2,4-bis(trifluoromethyl)benzene and 3-hydroxypyrrolidine by a method similar to that in Reference Example 1.

Sources & evidence

ORD record
ord-9dbc7c15e56b4586a34563508210f668
Source dataset
uspto-grants-2012_12
Patent number
US08338622B2

Reaction notes

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