3-Bromo-2-chlorobenzotrifluoride → HCID 67022300, compound

HRID 2198025Notes

Reaction equation

HRID 2198025 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:11])([F:10])[F:9])[C:3]=1[Cl:12].[NH:13]1[CH2:17][CH2:16][CH:15]([CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:14]1>>[Cl:12][C:3]1[C:4]([C:8]([F:11])([F:10])[F:9])=[CH:5][CH:6]=[CH:7][C:2]=1[N:13]1[CH2:17][CH2:16][CH:15]([CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:14]1

Participants

3

Reactant 2

HCID 32831733-Bromo-2-chlorobenzotrifluorideHCID 53428732Ethyl 3-(pyrrolidin-3-yl)propanoate

Product 1

HCID 67022300HCID 67022300, compoundYield 13%

Procedure

The title compound (895 mg, yield 13%) was obtained from 1-bromo-2-chloro-3-(trifluoromethyl)benzene and ethyl 3-(pyrrolidin-3-yl)propanoate obtained in Reference Example 12 by a method similar to that in Reference Example 1.

Sources & evidence

ORD record
ord-67dbc04ccd584680b738e36fa3bf6361
Source dataset
uspto-grants-2012_12
Patent number
US08338622B2

Reaction notes

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