Benzenamine, 3,5-bis(trifluoromethyl)- → HCID 86658340, compound

Participants

Reaction Steps

A solution of 3-chloropropanesulfonyl chloride (5.0 g) and 3,5-bis(trifluoromethyl)aniline (6.47 g) in pyridine (50 ml) was stirred at room temperature for 16 hr. The reaction solution was concentrated under reduced pressure, and the residue was partitioned between ethyl acetate and 1N hydrochloric acid. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under reduced pressure and the obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate 95:5-60:40) to give the title compound (7.20 g, yield 69%) as a pale-brown solid.

Provenance & Evidence