Benzene, 1-bromo-3-(trifluoromethyl)- → HCID 67022229, compound

HRID 2198039Notes

Reaction equation

HRID 2198039 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5](Br)[CH:6]=[CH:7][CH:8]=1.[OH:12][CH:13]1[CH2:17][CH2:16][NH:15][CH2:14]1>>[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([N:15]2[CH2:16][CH2:17][CH:13]([OH:12])[CH2:14]2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 9817Benzene, 1-bromo-3-(trifluoromethyl)-HCID 982104-Hydroxypyrrolidine

Product 1

HCID 67022229HCID 67022229, compoundYield 54%

Procedure

The title compound (2.67 g, yield 54%) was obtained from 3-(trifluoromethyl)phenyl bromide and 3-hydroxypyrrolidine by a method similar to that in Reference Example 1.

Sources & evidence

ORD record
ord-016d4d55662142a2b38e55446634df52
Source dataset
uspto-grants-2012_12
Patent number
US08338622B2

Reaction notes

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