Benzene, 1-bromo-4-(trifluoromethyl)- → HCID 62918160, compound

HRID 2198040Notes

Reaction equation

HRID 2198040 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][C:6](Br)=[CH:5][CH:4]=1.[OH:12][CH:13]1[CH2:17][CH2:16][NH:15][CH2:14]1>>[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][C:6]([N:15]2[CH2:16][CH2:17][CH:13]([OH:12])[CH2:14]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-HCID 982104-Hydroxypyrrolidine

Product 1

HCID 62918160HCID 62918160, compoundYield 55%

Procedure

The title compound (2.71 g, yield 55%) was obtained from 4-(trifluoromethyl)phenyl bromide and 3-hydroxypyrrolidine by a method similar to that in Reference Example 1.

Sources & evidence

ORD record
ord-78b07526036e4974ad014c1ca8f76028
Source dataset
uspto-grants-2012_12
Patent number
US08338622B2

Reaction notes

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