1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 67022252, compound

Participants

Reaction Steps

A solution of 3-bromo-5-(trifluoromethyl)benzoic acid (10 g), thiomorpholine (5.0 g), HOBt (7.4 g) and EDCI (9.26 g) in acetonitrile (113 ml) was stirred at room temperature for 16 hr. To the reaction mixture was added saturated aqueous sodium hydrogencarbonate solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated to give the title compound (12.3 g, yield 94%) a yellow oil.

Provenance & Evidence