HCID 58466015, compound → HCID 58466005, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of optically resolved tR1 (AS, 300 mg) of ({1-[3,5-bis(trifluoromethyl)phenyl]pyrrolidin-3-yl}sulfanyl)acetic acid obtained in Example 10 in acetone (10 mL) was added aqueous solution (5 ml) of Oxone-persulfate compound (500 mg) at 0° C., and the mixture was stirred at 0° C. for 1 hr. The reaction mixture was extracted with ethyl acetate, and the organic layer was dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated to give the title compound (291 mg, yield 93%) as a white solid.

Provenance & Evidence