HCID 58466015, compound → HCID 58466005, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of optically resolved tR2 (AS, 300 mg) of ({1-[3,5-bis(trifluoromethyl)phenyl]pyrrolidin-3-yl}sulfanyl)acetic acid obtained in Example 11 in acetone (10 mL) was added aqueous solution (5 mL) of Oxone-persulfate compound (500 mg) at 0° C., and the mixture was stirred at 0° C. for 1 hr. The acetone was evaporated under reduced pressure, and the precipitate was collected by filtration. The precipitate was washed with water and hexane to give the title compound (311 mg, yield 99%) as a white solid.

Provenance & Evidence