Tris(hydroxymethyl)aminomethane → HCID 87239817, compound

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Reaction Steps

To a solution of 3-{(2R,5S)-5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid (3.00 g, 8.42 mmol) obtained in Example 36 in methanol (60 mL) was added a solution of tromethamine (1.02 g, 8.42 mmol) in water (5 mL), and the mixture was stirred at room temperature for 2 hr. The solution was concentrated under reduced pressure, and the obtained solid was dissolved in ethyl acetate/toluene (10:1, 50 mL), and concentrated under reduced pressure. The obtained solid was disrupted in diisopropyl ether to give the title compound (3.79 g, yield 94%) as a white solid. Mp 110° C. Anal. Calcd. for C19H25NO6F6: C, 47.80; H, 5.28; N, 2.93. Found: C, 47.61; H, 5.47; N, 2.99.

Provenance & Evidence