Water → Methyl 4-Bromo-3-(bromomethyl)benzoate

Temperature

70 °C

Under N2, to a solution of methyl 4-bromo-3-methylbenzoate (Aldrich 532878, 50 g; 218.27 mmol; 1 eq.) in CHCl3 (1 000 mL) were added NBS (46.62 g; 261.93 mmol; 1.20 eq.) in one portion and α,α′-azoisobutyronitrile (0.72 g; 4.37 mmol; 0.02 eq.). The mixture was stirred at 70° C. for 2 days. The reaction mixture was cooled to RT and water (500 mL) was added. The organic layer was washed with 50 mL NaHCO3 sat. solution, water (340 mL), then brine (500 mL), dried over MgSO4 and concentrated affording the title compound as a yellow solid. It was washed with pentane (2×500 mL) affording the title compound as a yellow solid. 1H NMR (DMSO-d6, 300 MHz) δ 8.24 (d, J=1.91 Hz, 1H), 7.88-7.82 (m, 2H), 4.87 (s, 2H), 3.91 (s, 3H). HPLC (Method A) Rt 4.44 min (Purity: 97.9%).

1. temperatureThe reaction mixture was cooled to RT
2. washThe organic layer was washed with 50 mL NaHCO3 sat. solution, water (340 mL)
3. dry with materialbrine (500 mL), dried over MgSO4
4. concentrationconcentrated

ORD record

ord-dee0115ff80749abb4fb9a066cf53009

Source dataset

uspto-grants-2012_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08202865B2