Benzylamine → HCID 68794089, compound

HRID 2198257Notes

Reaction equation

HRID 2198257 reaction equation
[CH2:1]([CH:3]([CH2:21][CH3:22])[C:4]([NH:6][C:7]1[S:8][C:9]2[CH2:20][CH2:19][CH2:18][CH2:17][C:10]=2[C:11]=1[C:12]([O:14]CC)=O)=[O:5])[CH3:2].[CH2:23]([NH2:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH2:23]([NH:30][C:12]([C:11]1[C:10]2[CH2:17][CH2:18][CH2:19][CH2:20][C:9]=2[S:8][C:7]=1[NH:6][C:4](=[O:5])[CH:3]([CH2:1][CH3:2])[CH2:21][CH3:22])=[O:14])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 3635219HCID 3635219, compound

Product 1

HCID 68794089HCID 68794089, compound

Procedure

The product of Example 14 and benzylamine were processed as in Examples 29A and 29B to afford the title compound. 1H NMR (300 MHz, CD3OD) δ ppm 0.91 (t, J=7.5 Hz, 6H), 1.52-1.71 (m, 4H), 1.77-1.89 (m, 4H), 2.16-2.29 (m, 1H), 2.64-2.75 (m, 4H), 4.56 (s, 2H), 7.21-7.29 (m, 1H), 7.31-7.37 (m, 4H); MS (DCI/NH3) m/z 385 (M+H)+; anal. calculated for C22H28N2O2S: C, 68.72; H, 7.34; N, 7.28. Found: C, 68.45; H, 7.49; N, 7.17.

Sources & evidence

ORD record
ord-79361fe600b441d5898dab4a33263fe4
Source dataset
uspto-grants-2012_12
Patent number
US08338623B2

Reaction notes

Loading…