HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 219829Generated: October 25, 2026
Methanol → Methyl 4-chloro-3-(methylsulfonyl)benzoate
https://huagongshe.com/reaction/219829
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Chloro-3-methanesulfonylbenzoic acid | HCID 182670 | — |
| Product | Methyl 4-chloro-3-(methylsulfonyl)benzoate | HCID 10490815 | — |
Reaction Steps
4-chloro-3-(methylsulfonyl)benzoic acid (Enamine, 500 mg; 2.13 mmol; 1 eq.) was dissolved in MeOH (10 mL) The solution was cooled down to 0° C. Thionyl chloride (0.62 mL; 8.52 mmol; 4 eq.) was added dropwise.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08202865B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-d51a0ee0e54e4df4aaae02a934a574d4 |
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| Source note | uspto-grants-2012_06 |
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