HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Formaldehyde → 9-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-2,3,4,9-tetrahydro-2,6-dimethyl-1H-pyrido[3,4-b]indole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Formaldehyde | HCID 712 | — |
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | 4-Methylphenylhydrazine monohydrochloride | HCID 12504 | — |
| Edukt | 4,4-Diethoxy-N-methylbutan-1-amine | HCID 13994547 | — |
| Edukt | 5-(2-(1-p-Tolylhydrazinyl)ethyl)-2-(trifluoromethyl)pyridine | HCID 66601798 | — |
| Edukt | 5-(2-Bromoethyl)-2-(trifluoromethyl)pyridine | HCID 66869537 | — |
| Edukt | 2-(1-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5-methyl-1H-indol-3-yl)-N-methylethanamine | HCID 66911743 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Lösungsmittel | Triethylamine | HCID 8471 | — |
| Produkt | 9-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-2,3,4,9-tetrahydro-2,6-dimethyl-1H-pyrido[3,4-b]indole | HCID 44242178 | — |
Reaktionsschritte
The title compound is prepared by following General Methods 1, 3 and 4 using p-tolylhydrazine hydrochloride, 5-(2-bromoethyl)-2-(trifluoromethyl)pyridine, and triethylamine (General Method 1), 1-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-1-p-tolylhydrazine (Example 2) and 4,4-diethoxy-N-methylbutan-1-amine (General Method 3) and 2-(1-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5-methyl-1H-indol-3-yl)-N-methylethanamine (Example 11), formaldehyde and TFA in acetonitrile (General Method 4).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08338447B2 |
| Quelldatensatz | uspto-grants-2012_12 |
| ORD ID | ord-1b589899655a4ef0a1525ec8dfc264ef |
| Quellennotiz | uspto-grants-2012_12 |