Formaldehyde → 7-chloro-2-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

HRID 2198300Notes

Reaction equation

HRID 2198300 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]3[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][C:7]=3[N:8]2CC(C2C=NC(C)=CC=2)O)=[CH:4][CH:3]=1.ClC1C=C(NN)C=CC=1.COC(OC)CCCNC.ClC1C=C2C(C(CCNC)=CN2)=CC=1.C=O>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]3[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][C:7]=3[NH:8]2)=[CH:4][CH:3]=1

Participants

6

Reactant 5

HCID 712FormaldehydeHCID 75332(3-Chlorophenyl)hydrazineHCID 21071655[2-(6-Chloro-1h-indol-3-yl)ethyl](methyl)amineHCID 22563572(4,4-Dimethoxybutyl)(methyl)amineHCID 442421802-(7-chloro-2-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-9(2H)-yl)-1-(6-methylpyridin-3-yl)ethanol

Product 1

HCID 579304787-chloro-2-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Procedure

Method for the preparation of compound 7 [[2-(7-chloro-2-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-9(2H)-yl)-1-(6-methylpyridin-3-yl)ethanol]: (3-chlorophenyl)hydrazine is reacted with 4,4-dimethoxy-N-methylbutan-1-amine (put in the references for this) to generate 2-(6-chloro-1H-indol-3-yl)-N-methylethanamine, which upon treatment with formaldehyde, under standard Pictet Spingler reaction conditions (insert the reference for this) gives 7-chloro-2-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole. The further reaction of this unsubstituted β-carboline with 2-methyl-5-(oxiran-2-yl)pyridine (carboline, aryl/heteroaryl oxide, NaH, DMF, 120° C.) gives the desired compound 2-(7-chloro-2-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-9(2H)-yl)-1-(6-methylpyridin-3-yl)ethanol, compound 7. After the successful synthesis of the compound, purification can be achieved using standard normal phase or reverse phase methods.

Workup

  1. customunder standard Pictet Spingler reaction conditions (insert the reference for this)

Sources & evidence

ORD record
ord-6f4c0a070d96472fbff70f4473f5b0ae
Source dataset
uspto-grants-2012_12
Patent number
US08338447B2

Reaction notes

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