HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 44242574, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | m-Chlorophenylhydrazine hydrochloride | HCID 75331 | — |
| Reactant | 4,4-Diethoxy-N-methylbutan-1-amine | HCID 13994547 | — |
| Reactant | HCID 66911678 | HCID 66911678 | — |
| Reactant | HCID 66911687 | HCID 66911687 | — |
| Reactant | HCID 66911765 | HCID 66911765 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Solvent | HCID 66911674 | HCID 66911674 | — |
| Product | HCID 44242574 | HCID 44242574 | — |
Reaction Steps
The title compound is prepared by following General Methods 1, 3, 4, 5 and 7 by using 3-chlorophenylhydrazine hydrochloride, ethyl bromoacetate, and triethylamine (General Method 1), ethyl 2-(1-(3-chlorophenyl)hydrazinyl)acetate and 4,4-diethoxy-N-methylbutan-1-amine (General Method 3), ethyl 2-(6-chloro-3-(2-(methylamino)ethyl)-1H-indol-1-yl)acetate, formaldehyde and TFA in acetonitrile (General Method 4), ethyl 2-(7-chloro-1,2,3,4-tetrahydro-2-methylpyrido[3,4-b]indol-9-yl)acetate and NaOH (General Method 5), and 2-(7-chloro-1,2,3,4-tetrahydro-2-methylpyrido[3,4-b]indol-9-yl)acetic acid, piperidine and EDCI (General Method 7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338447B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-00e74d246720464d8768951cd12716d7 |
| Source note | uspto-grants-2012_12 |