HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 57930358, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Propargyl bromide | HCID 7842 | — |
| Reactant | Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1) | HCID 71600 | — |
| Reactant | 4,4-Diethoxy-N-methylbutan-1-amine | HCID 13994547 | — |
| Reactant | HCID 86635501 | HCID 86635501 | — |
| Reactant | HCID 86635502 | HCID 86635502 | — |
| Catalyst | Tetrabutylammonium Chloride | HCID 70681 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 57930358 | HCID 57930358 | — |
Reaction Steps
The title compound was prepared by following General Methods 2, 3 and 4 using 4-chlorophenylhydrazine hydrochloride, propargyl bromide, and tetra-n-butylammonium chloride (General Method 2), 1-(4-chlorophenyl)-1-(prop-2-ynyl)hydrazine (Example 8) and 4,4-diethoxy-N-methylbutan-1-amine (General Method 3) and 2-(5-chloro-1-(prop-2-ynyl)-1H-indol-3-yl)-N-methylethanamine (Example 17), formaldehyde and TFA in acetonitrile (General Method 4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338447B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-b78e14d544a44c878d83d106386504a7 |
| Source note | uspto-grants-2012_12 |