Iodine → HCID 20519459, compound

Participants

Reaction Steps

5.35 g of magnesium chips and a little iodine are added to a solution of 3 g of 2,6-dichlorobenzyl chloride in 20 ml of diethyl ether. After brief heating, the reaction begins, after which another 36.1 g of 2,6-dichlorobenzyl chloride dissolved in 230 ml of diethyl ether are added dropwise at boiling temperature. A solution of 18.9 g of 2,2',4'-trichloroacetophenone in 150 ml of ether is then added dropwise, and the mixture left to react for 2 hours. The reaction mixture is then treated with an aqueous ammonium chloride solution, the ethereal phase is dried over sodium sulphate and concentrated in vacuo. Treatment of the solid residue with isopropyl ether gives 19.3 g of 1-(2,6-dichlorophenyl)-2-(2,4-dichlorophenyl)-3-chloropropan-2-ol melting at 117° C.

Provenance & Evidence