HCID 86754917, compound → Cefadroxil monohydrate

Participants

Reaction Steps

The DMF-solvate of Step C was added in portions and with stirring in about 10 minutes to 175 ml of distilled water at room temperature. After the addition and dissolution of 5 g of the solvate, 1 g of seeding crystals of cefadroxil-monohydrate were added to the mixture. After the complete addition, stirring was continued for one hour and the pyramidal crystals were filtered and washed with water at 0° C. and dried under vacuo at about 30° C. to obtain 35.4 g of crystalline white cefadroxil monohydrate. The structure of the compound was confirmed by IR and PMR spectra and showed a high purity of the product. The mother liquor was evaporated to 50 ml and after addition of 600 ml of DMF, 21.3 g of the same solvate were recovered for an overall yield of 78% of cefadroxil based on the starting 7-ADCA.

Provenance & Evidence