HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminum(III) Chloride → 6-Benzoyloxy-2-(4-benzoyloxyphenyl)-3-[4-(2-pyrrolidinoethoxy)benzoyl]benzo[b]thiophene, hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 4-(6-(Benzoyloxy)benzo[b]thiophen-2-yl)phenyl benzoate | HCID 9911604 | — |
| Reactant | 4-(2-Pyrrolidin-1-ylethoxy)benzoic acid hydrochloride | HCID 13174868 | — |
| Product | 6-Benzoyloxy-2-(4-benzoyloxyphenyl)-3-[4-(2-pyrrolidinoethoxy)benzoyl]benzo[b]thiophene, hydrochloride | HCID 131712865 | — |
Reaction Steps
An acid chloride was formed from 18.1 g. of 4-(2-pyrrolidinoethoxy)benzoic acid, hydrochloride, as described in Example 1. The acid chloride was used to acylate 20 g. of 6-benzoyloxy-2-(4-benzoyloxyphenyl)benzo[b]thiophene as described above in Example 1, using 53.2 g. of aluminum chloride. A sample of the impure product, a tan foam, was recrystallized from denatured ethanol to obtain an analytical sample, m.p. 218°-222°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04358593 |
| Source dataset | uspto-grants-1982_11 |
| ORD ID | ord-f84fc074755c4c86bd850b62b0c52afd |
| Source note | uspto-grants-1982_11 |