Phenol → HCID 19825286, compound

Participants

Reaction Steps

Repeating the process of Example 5 using 470 g (5 moles) of phenol in place of the xylenol, yielded a reaction mixture consisting of 66% of 4,4-(1-methyltrifluoroethylidene)bisphenol and 34% of 2,4'-(1-methyltrifluoroethylidene)bisphenol. After the removal of excess phenol by distillation, the mixture of the two isomers was readily separated by elution chromatography over silica, using methylene chloride as eluant. After the emergence of the 2,4'-isomer, the 4,4'-isomer was eluted. The 4,4'-isomer crystallized out readily from the concentrated solution in the form of white crystals which melted at 93°-94.5° C. and had a purity of 98.2%.

Provenance & Evidence