HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoroaniline → HCID 13014494, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoroaniline | HCID 9731 | — |
| Reactant | ethyl N-(2-cyano-3-ethoxyacryloyl)carbamate | HCID 230015 | — |
| Solvent | Tetralin | HCID 8404 | — |
| Product | HCID 13014494 | HCID 13014494 | — |
Reaction Steps
Following the method of Example 2, 4-fluoroaniline (0.05 mol) is reacted with α-cyano-β-ethoxy-N-ethoxycarbonylacrylamide (0.05 mol) and heated at reflux in tetralin to yield 5-cyano-1-(4-fluorophenyl)uracil, which is then reacted with trichloromethanesulfenyl chloride, in NaOH and dichloromethane, to yield the final product, 5-cyano-1-(4-fluorophenyl)-3-trichloromethanesulfenyluracil, m.p. 163°-165.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04358591 |
| Source dataset | uspto-grants-1982_11 |
| ORD ID | ord-ab66950cf138435b8af1f4b9defe8052 |
| Source note | uspto-grants-1982_11 |