反应详情

温度

50 °C

Methyl 4-amino-2-fluoro-5-methoxybenzoate (100 mg; 0.50 mmol; 1 eq.) was dissolved in MeOH (2 mL). NaOH (0.50 mL; 5 M; 2.51 mmol; 5 eq.) was added and the mixture was heated at 50° C. overnight. The solvents were evaporated. EtOAc was added and the resulting solution was washed with NH4Cl sat. The aqueous phase was extracted with EtOAc. Combined organic phases were dried over MgSO4, filtrated and evaporated, affording the title compound (92 mg; 99%). HPLC (Method A) Rt 1.92 min (Purity: 96.4%).

1. customThe solvents were evaporated
2. additionEtOAc was added
3. washthe resulting solution was washed with NH4Cl sat. The aqueous phase
4. extractionwas extracted with EtOAc
5. dry with materialCombined organic phases were dried over MgSO4
6. filtrationfiltrated
7. customevaporated