HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonic Acid → Carnosine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | Tetramethylammonium hydroxide | HCID 60966 | — |
| Reactant | 1,3-thiazinane-2,4-dione | HCID 2304067 | — |
| Reactant | HCID 178419078 | HCID 178419078 | — |
| Product | Carnosine | HCID 439224 | 50% |
Reaction Steps
Starting with 1.55 g. (10 mmol) of L-histidine, 2.62 g. (20 mmol) of tetrahydro-1,3-thiazin-2,4-dione, 20% aqueous tetramethylammonium hydroxide solution to raise the pH and methanesulfonic acid to lower the pH, and following the procedure of Example 1, there was isolated 1.13 g. (50% yield) of L-carnosine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04359416 |
| Source dataset | uspto-grants-1982_11 |
| ORD ID | ord-f44b0137363241e19cb3774ee96866d1 |
| Source note | uspto-grants-1982_11 |